阿普唑仑 (ａｌｐｒａｚｏｌａｍ ,ＡＬＰ)为临床常用的镇静、催眠和抗焦虑药 ,广泛用于失眠、焦虑症、抑郁症、神经衰弱、癔病、精神分裂症、癫痫、强迫症和惊恐症等多种神经精神疾病的治疗。为提供临床合理用药参考资料 ,本文对大鼠灌胃阿普唑仑后血药浓度的个体差异及其药代 Alprazolam (ALP) is a common sedative, hypnotic and anti-anxiety drug widely used in insomnia, anxiety, depression, neurasthenia, hysteria, schizophrenia, epilepsy, obsessive compulsive disorder and panic disorder Treatment of neuropsychiatric disorders. In order to provide a reference for clinical rational use of drugs, this paper on rats after oral administration of alprazolam plasma concentration differences and their pharmacokinetics