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随着新药研究的不断发展,新的药物剂型也不断出现,脂质体就是近年发展起来的一种新剂型。它是将药物包封在由类脂质双分子层构成的薄膜中间,从而制成的一种超微型球状载体制剂。脂质体的膜层主要为磷脂和胆固醇,磷脂包括卵磷脂、脑磷脂、大豆磷脂以及其他合成磷脂等,这些极性磷脂在水溶液中可以形成一层或多层同中心的双分子磷脂片层复合物,在片层之间和中心充满水溶液。水溶性物质如蛋白质、酶、核酸病毒等可被包裹在水相中,而脂溶性药物则被包裹在磷脂中。胆固醇也是构成脂质体的主要成分,而且近年来的研究表明,它还具有一定的抗肿瘤
With the continuous development of new drug research, new drug dosage forms are emerging constantly. Liposomes are a new type of dosage forms developed in recent years. It is the drug encapsulated in lipid-like bilayer membrane formed in the middle, which made of an ultra-micro spherical carrier preparation. Liposomes are mainly composed of phospholipids and cholesterol, phospholipids including lecithin, cephalin, soya lecithin and other synthetic phospholipids, etc. These polar phospholipids can form one or more concentric bilayer phospholipid lamellae in aqueous solution Complex, between the layers and the center is filled with an aqueous solution. Water-soluble substances such as proteins, enzymes, nucleic acids and the like can be encapsulated in the aqueous phase while the fat-soluble drugs are encapsulated in phospholipids. Cholesterol is also the main component of liposomes, and in recent years, studies have shown that it also has some anti-tumor