According to the features of the basins in arid areas, in this paper a quantified study framework of sustainable management of water resources is developed, and the contents include mainly the quanti-fication rules, index system, basic models and quantification method. A quantified study method (M-D method) about sustainable management of water resources is put forward based on the simulation and integrative development degree. In the method, the fuzzy subordinatness description and the multi-rule integration are used to calculate the integrative development degree so as to quantitatively describe the sustainable development degree of economic society; the mathematical simulation is used to quantitatively describe the interactions between water resources, economic society and ecosystems so as to lay a foundation for quantitatively giving expression to the development situation of economic society related to the management of water resources; based on the organic combination of these two, quantification rules and other constraint conditions, a quantified model of water resources manage-ment is developed. The M-D method is applied to developing a scientific scheme of water resources management in the Bosten Lake Basin, Xinjiang, China. According to the features of the basins in arid areas, in this paper a quantified study framework of sustainable management of water resources is developed, and the contents include mainly the quanti- fication rules, index system, basic models and quantification method. A quantified study method (MD method) about sustainable management of water resources is put forward based on the simulation and integrative development degree. In the method, the fuzzy subordinatness description and the multi-rule integration are used to calculate the integrative development degree so as to quantitatively describe the sustainable development degree of economic society; the mathematical simulation is used to quantitatively describe the interactions between water resources, economic society and ecosystems so as to lay a foundation for quantitatively giving expression to the development situation of economic society related to the management of water resources ; based on the organic combination of these tw o, quantification rules and other constraint conditions, a quantified model of water resources manage-ment was developed. The M-D method is applied to developing a scientific scheme of water resources management in the Bosten Lake Basin, Xinjiang, China.