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目的回顾性分析11例输入性罗阿丝虫病患者的临床特征。方法收集首都医科大学附属北京友谊医院2012年1月-2016年7月确诊的11例输入性罗阿丝虫病患者临床和实验室数据并进行分析。结果 11例罗阿丝虫病患者均有罗阿丝虫疫区工作生活史。患者均有游走性皮下肿块,94.0%伴有瘙痒,1例患者检出眼结膜成虫。45.45%的患者进行了T淋巴细胞亚群和免疫球蛋白抗体检测,其中IgE抗体水平增高,丝虫抗原阳性。1例患者丝虫IgG4抗体阳性。血查微丝蚴均阴性。所有患者口服均阿苯达唑治疗,治疗1个疗程9例,2个疗程治疗2例,3例出现不良反应,所有患者至今随访无复发。结论综合流行病学史分析,有游走性皮下肿块,血嗜酸性粒细胞增多,丝虫抗原和抗体阳性可诊断为罗阿丝虫病。阿苯达唑单一用药治疗罗阿丝虫病效果良好。
Objective To retrospectively analyze the clinical features of 11 cases of Loach’s disease. Methods The clinical and laboratory data of 11 cases of imported Loach’s disease diagnosed in Beijing Friendship Hospital of Capital Medical University from January 2012 to July 2016 were collected and analyzed. Results 11 cases of Loach filariasis patients have loa filariasis work life history. Patients had migratory subcutaneous tumors, 94.0% with pruritus, and 1 patient with conjunctival. 45.45% of the patients were T lymphocyte subsets and immunoglobulin antibody detection, in which IgE antibody levels increased, filarial antigen positive. One patient was positive for filarial IgG4 antibody. Blood check microfilariae were negative. All patients were treated with albendazole orally. There were 9 cases of 1 course of treatment, 2 cases of 2 courses of treatment and 3 cases of adverse reactions. All patients had no recurrence so far. Conclusion Epidemiological analysis of history, there are migratory subcutaneous tumors, blood eosinophilia, filarial antigen and antibody positive diagnosis of lohriosis. Albendazole single drug treatment Loa filariasis good effect.