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过去,人们一直认为SMZ和SD是短效磺胺,有些医生在用药时间隔时间太短,药量过大。为了克服磺胺药在肝脏内代谢后会形成乙酰化代谢产物,在酸性尿液中溶解度小,易形成结晶而引起血尿、少尿,故常同服SB。近年来,临床实践证明,这两种磺胺属于中效(每日1～2次即可)。口服剂量少,间隔时间较长,则排泄慢,溶解度较好,排泄的代谢产物较少,一般情况下很少引起血尿,故不需同服SB。
In the past, people always think SMZ and SD are short-acting sulfonamides, some doctors in the medication interval is too short, overdosage. In order to overcome the metabolism of sulfa drugs in the liver will form acetylated metabolites, solubility in acidic urine is small, easy to form crystals and cause hematuria, oliguria, so often with the service SB. In recent years, clinical practice has proved that the two sulfonamides are in effect (1 or 2 times a day can be). Oral doses of less interval longer, then excretion slow, better solubility, less excreted metabolites, under normal circumstances rarely cause hematuria, it is not the same service SB.