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目的比较米索前列醇和人绒毛膜促性腺激素(HCG)这两种药物在临床的促排卵效果及妊娠结局。方法选取2009年4月-2011年4月在内蒙古妇幼保健医院生殖内分泌门诊就诊的Ⅱ型生殖内分泌异常的不育妇女90例,在月经周期第3日起开始口服来曲唑促排卵,连服5日,剂量为5mg/日。于月经周期的10日开始阴道B超监测卵泡,直至优势卵泡直径≥18mm,共85例。无卵巢高反应性者为A组,共70例,给予肌注HCG 6000U;出现卵巢高反应性或预测可能出现卵巢过度刺激综合征(OHSS)者为B组,共15例,给予口服米索前列醇0.2 mg。通过阴道B超监测排卵征象,测定基础体温及超声最终明确早孕。结果 HCG组与米索前列醇组排卵成功率与无显著性差异(P>0.05),两组的妊娠率亦无显著性差异(P>0.05)。结论米索前列醇与HCG的临床促排卵效果无显著性差异,米索前列醇作用温和,对于促排卵过程中出现卵巢高反应性或过度刺激综合征倾向者,在HCG日应用米索前列醇诱发排卵,是较为理想的替代选择。
Objective To compare the ovulation induction effect and pregnancy outcome of two drugs, misoprostol and human chorionic gonadotropin (HCG). Methods From April 2009 to April 2011, 90 infertile women with type Ⅱ reproductive and endocrine abnormalities in the Reproductive and Endocrinology Clinic of MCH Hospital of Inner Mongolia were enrolled. Oral letrozole was orally administered on the 3rd day of the menstrual cycle, On the 5th, the dose is 5mg / day. On the 10th of the menstrual cycle, vaginal B-monitoring of follicles began, until the dominant follicle diameter ≥ 18mm, a total of 85 cases. A group of patients with no ovary hyperresponsiveness, A total of 70 patients were given intramuscular HCG 6000U; ovarian hypersensitivity or ovarian hyperstimulation syndrome (OHSS) were predicted for the B group, a total of 15 cases, given oral misoprostol PRoprolol 0.2 mg. Ovulation signs monitored by vaginal ultrasound B, determination of basal body temperature and ultrasound finally clear pregnancy. Results There was no significant difference in the success rate of ovulation between HCG group and misoprostol group (P> 0.05). There was no significant difference in pregnancy rates between the two groups (P> 0.05). Conclusion There was no significant difference in the effect of misoprostol and HCG on ovulation induction. Misoprostol was mild. For those patients who had ovarian hyperstimulation or hyperstimulation syndrome during ovulation induction, misoprostol Induced ovulation, is an ideal alternative.