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目的:研究温心宝口服液对豚鼠急性心衰左心室功能的影响。方法:从颈动脉插心导管入左心室的方法测定其压力及压力的变化 ,以评价心室功能和顺应性 ,用普萘洛尔致心衰 ,以哇巴因为阳性对照 ,观察温心宝口服液对豚鼠急性心衰时左心室功能的影响。 结果 :口服温心宝口服液小剂量 (5 ml/kg)和中剂量 (10 ml/kg)对L VSP(左心室内压峰值 )无显著影响 ,大剂量 (2 0 ml/kg)则降低 L VSP;用普萘洛尔致心衰 10 min,3个剂量组均使L VSP升高或恢复正常 ;中剂量温心宝组使普萘洛尔致心衰心脏的 +dp/dtmax(左室内压最大上升速率 )及 - dp/dtmax(左室内压最大下降速率 )在 10 min恢复正常。静脉点滴温心宝时 ,L VSP、+dp/dtmax及 - dp/dtmax和 dp/dt/P40(左室内压达 40 mm Hg时心肌收缩速度 )也均升高。 结论 :温心宝可改善心衰 ,使衰竭心肌的收缩性恢复 ,静脉给药比口服给药作用更显著。
Objective: To study the effect of Wenxinbao oral liquid on left ventricular function of acute heart failure in guinea pigs. METHODS: Changes in pressure and pressure were measured from a carotid artery catheter inserted into the left ventricle to evaluate ventricular function and compliance. Heart failure was induced with propranolol, and ouabain was used as a positive control to observe Wenxinbao oral solution. Left Ventricular Function in Acute Heart Failure in Guinea Pigs . RESULTS: Oral administration of Wenxinbao Oral Liquid had no significant effect on L VSP (peak left ventricular pressure) in small doses (5 ml/kg) and moderate dose (10 ml/kg). Large doses (20 ml/kg) decreased L VSP. Propranolol caused heart failure for 10 min, all three doses increased L VSP or returned to normal; middose Wen Xin Bao group caused propranolol-induced heart failure +dp/dtmax (maximal rise in left ventricular pressure Rate) and -dp/dtmax (the maximum rate of left intraventricular pressure drop) returned to normal at 10 min. At the time of intravenous infusion of Wenxinbao, L VSP, +dp/dtmax, and -dp/dtmax, and dp/dt/P40 (myocardial contractile velocity at left intraventricular pressure up to 40 mm Hg) also increased. Conclusion : Wen Xin Bao can improve heart failure and restore the contractility of failing myocardium. Intravenous administration is more effective than oral administration.