原发性肝癌是我国发病率最高的恶性肿瘤,约占全世界的55%,其平均发病年龄为43.7岁,死亡率居我国第二,呈逐年上升趋势~[1]。目前首选的治疗方式仍是手术切除,但由于肝癌的临床表现极不典型,大多数患者被确诊为肝癌时已发展为中晚期,能够手术切除治愈的不超过25%,即使行外科手术治疗,其术后复发率也高达65%~[2]。对不能手术的肝癌患者,治疗方式主要有射频消融、介入治疗、微波消融、局部放疗及高强度聚焦 Primary liver cancer is the highest incidence of malignant tumors in China, accounting for about 55% of the world, the average age of onset is 43.7 years old, the mortality rate ranks second in China, showing an upward trend year by year ~ [1]. At present, the preferred treatment is still surgical resection. However, because the clinical manifestations of liver cancer are not typical, most patients have been diagnosed as having advanced liver cancer, and no more than 25% of them can be cured by surgery, even if they are treated with surgery. The postoperative recurrence rate is as high as 65%~[2]. For patients with unresectable liver cancer, the treatment methods include radiofrequency ablation, interventional therapy, microwave ablation, local radiotherapy and high-intensity focusing