论文部分内容阅读
目的 :观察氯沙坦治疗充血性心力衰竭 (CHF)的临床疗效。方法 :3 8例经常规洋地黄、利尿剂、血管扩张药等治疗效果欠佳的CHF患者 ,给予口服氯沙坦 2 5～ 10 0mg/d ,治疗 4～ 6周。观察治疗前后心率、心胸比、血压、左室舒张末期内径、左室射血分数以及心功能的变化。结果 :治疗后心率、血压、心胸比以及左室舒张末期内径与治疗前比较均明显下降 (P <0 0 5、P <0 0 1)。左室射血分数增加 (P <0 0 1) ,心功能改善 1～ 2级。药物副作用少 ,患者耐受性好。结论 :氯沙坦治疗CHF疗效好 ,副作用较少 ,是慢性心力衰竭新的治疗药物
Objective: To observe the clinical efficacy of losartan in the treatment of congestive heart failure (CHF). Methods: Thirty-eight CHF patients with routine treatment of digitalis, diuretics and vasodilators were treated with losartan 25 ~ 100 mg / d for 4 to 6 weeks. Heart rate, cardiothoracic ratio, blood pressure, left ventricular end-diastolic diameter, left ventricular ejection fraction and cardiac function were observed before and after treatment. Results: After treatment, heart rate, blood pressure, cardiothoracic ratio, and left ventricular end-diastolic diameter were significantly decreased compared with those before treatment (P <0.05, P <0.01). Left ventricular ejection fraction increased (P <0.01), and heart function improved 1 ~ 2. Less side effects of drugs, patients are well tolerated. Conclusion: Losartan in the treatment of CHF has a good curative effect with few side effects and is a new therapeutic drug for chronic heart failure