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目的探讨槲皮素对TRAMP-C2前列腺癌小鼠模型的抑制作用及其机制。方法建立前列腺癌细胞株TRAMP-C2小鼠模型并随机分成4组。A组(对照组)；B组(槲皮素25 mg/ kg体重治疗组)；C组(槲皮素50 mg/kg体重治疗组)；D组(槲皮素100 mg/kg体重治疗组)。观察槲皮素对各组小鼠的抑瘤作用并检测各组肿瘤标本的微血管密度计数。结果接种5周后A、B、C、D各组小鼠的肿瘤重量分别为(1．85±0．23)、(1．61±0．10)、(1．10±0．17)、(0．79±0．11)g,治疗组明显低于对照组(P＜0．01),B、C、D组的抑瘤率分别为13%、41%、57%。各组肿瘤的微血管密度计数分别为39．29±6．39,31 61±4．82,23．42±3．91,14．00±4．01,治疗组明显减少(P＜0．05)。结论槲皮素可抑制前列腺癌细胞株TRAMP-C2小鼠移植瘤的生长；其机制可能与抑制肿瘤组织血管生成有关。
Objective To investigate the inhibitory effect of quercetin on TRAMP-C2 prostate cancer mouse model and its mechanism. Methods The prostate cancer cell line TRAMP-C2 mouse model was established and randomly divided into 4 groups. Group B (quercetin 25 mg / kg body weight treatment group); Group C (quercetin 50 mg / kg body weight treatment group); Group D (quercetin 100 mg / kg body weight treatment group ). To observe the anti-tumor effect of quercetin in each group of mice and to detect the microvessel density of tumor specimens in each group. Results The tumor weights of mice in groups A, B, C and D after vaccination for 5 weeks were (1.85 ± 0.23), (1.61 ± 0.10) and (1.10 ± 0.17), respectively , (0.79 ± 0.11) g, the treatment group was significantly lower than the control group (P <0.01), and the tumor inhibition rates of group B, C and D were 13%, 41% and 57%, respectively. The microvessel density count of each group was 39.29 ± 6.39, 3161 ± 4.82, 23.42 ± 3.91 and 14.00 ± 4.01 respectively, and the treatment group was significantly reduced (P <0.05 ). Conclusions Quercetin can inhibit the growth of transplanted tumor of prostate cancer cell line TRAMP-C2 in mice. The mechanism may be related to the inhibition of tumor angiogenesis.