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目的 探讨狼疮性肾炎患者肺功能损害的特征。方法 测定 36例狼疮性肾炎患者的肺容量、通气功能、小气道功能和弥散功能 ,并与健康人作对照。结果 30 %的患者呈现肺气肿现象 ,30 %的患者肺通气功能减低 ,小气道阻塞和可疑小气道阻塞者占 6 0 % ,有 83 %的患者合并肺弥散功能减退 ;与对照组比较 ,VC ,RV/TLC ,FEV1,MVV ,DLCO及DLCO/VA差异有显著性 (P <0 .0 5 ) ;相关因素分析表明 ,DLCO与TLC呈显著正相关。结论 狼疮性肾炎患者肺功能损害以弥散功能减退为主要特征 ,其次可见小气道阻塞、肺气肿和肺通气功能减低 ,这些改变最终导致患者呈现混合性通气障碍为主的肺功能改变
Objective To investigate the characteristics of lung dysfunction in patients with lupus nephritis. Methods Thirty-six patients with lupus nephritis were enrolled in this study. Their lung volume, ventilation, small airway function and diffusion were measured and compared with healthy controls. Results Thirty percent of the patients showed emphysema, 30% of the patients had decreased lung ventilation, 60% had small airway obstruction and suspicious small airway obstruction, and 83% had pulmonary diffuse dysfunction. Compared with the control group, The differences of VC, RV / TLC, FEV1, MVV, DLCO and DLCO / VA were significant (P <0.05). Correlation analysis showed that there was a significant positive correlation between DLCO and TLC. Conclusions Pulmonary function impairment in patients with lupus nephritis is mainly characterized by diffuse dysfunction. Second, small airway obstruction, emphysema and decreased pulmonary ventilation are observed. These changes eventually lead to pulmonary dysfunction in patients with mixed ventilatory disorders