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目的探讨厚朴滴丸不同处方配比对止泻作用的影响。方法采用小鼠番泻叶致泻模型观察该方不同配比的止泻作用,并以均匀设计方法用于筛选最佳处方配比的研究。结果厚朴滴丸处方配比中考虑古方用量同时结合实际提取率的样品止泻效果最好;理论优化的结果与厚朴丸原方的用量比较接近,厚朴∶黄连∶木香∶干姜(3.5∶3∶0.75∶1)。结论采用合适的药效模型,结合中医药理论的指导,配合数学方法处理分析结果,可为临床应用和新药开发提供参考。
Objective To investigate the effect of different prescription prescriptions of Houpu Dripping Pills on the antidiarrheal effect. Methods The diarrhea model of mice was used to observe the antidiarrheal effect of different ratios of the prescription, and the uniform design method was used to select the best prescription prescription. Results The anti-diarrhoea effect was best in the prescription of the combination of the ancient recipe dosage and the actual extraction rate. The result of the theoretical optimization was similar to the amount of Houpu Pill original formula. Houpu: Coptis: woody: ginger (3.5:3:0.75:1). Conclusion The appropriate pharmacodynamic model, combined with the guidance of traditional Chinese medicine theory, and the mathematical analysis of the results can provide reference for clinical application and development of new drugs.