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目的探讨西酞普兰治疗维持性血液透析患者抑郁状态的疗效。方法采用西酞普兰对符合抑郁状态的维持性血液透析患者进行为期6周的治疗观察。采用汉密顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和不良反应。结果治疗后各周HAMD评分分别与治疗前比较,均显著降低,差异均有统计学意义(P<0.05或P<0.01),不良反应少而轻。结论西酞普兰治疗维持性血液透析患者抑郁状态安全有效,可有效改善患者的生活,治疗依从性好,适合临床使用。
Objective To investigate the efficacy of citalopram in the treatment of depression in maintenance hemodialysis patients. METHODS: Citalopram was used to treat patients with maintenance hemodialysis in a depressive state for 6 weeks. The efficacy and adverse reactions were assessed using the HAMD and TESS. Results The HAMD scores of each week after treatment were significantly lower than those before treatment, the differences were statistically significant (P <0.05 or P <0.01), adverse reactions were less and less. Conclusion Citalopram treatment of patients with maintenance hemodialysis depression is safe and effective, can effectively improve the lives of patients with good compliance, suitable for clinical use.