论文部分内容阅读
目的通过检测结缔组织生长因子(CTGF)在糖尿病肾病(DN)患者外周血中的含量,观察缬沙坦及氟伐他汀治疗前后对24h尿白蛋白排泄率(UAER)和CTGF的影响,探讨DN的发病机制及治疗方法。方法选取我院DN住院患者20例,选取年龄相匹配的健康志愿者20例为对照组(NC组)。根据用药情况将DN患者分为DN+缬沙坦治疗组(DA组)、DN+氟伐他汀治疗组(DF组),观察3个月。应用ELISA法检测血中CTGF浓度,并检测患者24h尿白蛋白排泄率(UAER),进行组间及治疗前后比较。结果 DN组患者治疗前血CTGF浓度较NC组明显增多(P<0.01);与治疗前比较,DA组、DF组血CTGF浓度均减少(P<0.05),但DA组下降的程度与DF组比较,差异无统计学意义(P>0.05)。治疗后DA组、DF组24h尿白蛋白排泄率(UAER)减少(P<0.01),但DA组下降的程度与DF组比较,差异无统计学意义(P>0.05)。结论 CTGF在DN患者血中浓度增加,其在DN发病过程中起重要作用。氟伐他汀及缬沙坦通过降低CTGF来改善DN病情。
Objective To investigate the effects of CTX on the serum levels of urinary albumin excretion (UAER) and CTGF before and after treatment with valsartan and fluvastatin in diabetic nephropathy (DN) The pathogenesis and treatment. Methods Twenty patients with DN in our hospital were selected and 20 healthy volunteers of the same age were selected as the control group (NC group). DN patients were divided into DN + valsartan treatment group (DA group) and DN + fluvastatin treatment group (DF group) according to the medication situation and observed for 3 months. The concentration of CTGF in the blood was detected by ELISA, and the urinary albumin excretion rate (UAER) was measured 24 hrs before and after treatment. Results Compared with NC group, the CTGF concentration in DN group was significantly higher than that in NC group (P <0.01). Compared with before treatment, the serum CTGF concentration in DA group and DF group decreased (P <0.05) The difference was not statistically significant (P> 0.05). The urinary albumin excretion rate (UAER) of DA group and DF group decreased after treatment (P <0.01), but there was no significant difference between DA group and DF group (P> 0.05). Conclusion The concentration of CTGF in the blood of DN patients increases, which plays an important role in the pathogenesis of DN. Fluvastatin and valsartan improve DN by reducing CTGF.