目的介绍抗菌药物的PAE对临床合理用药的指导作用,促进抗菌药物的合理应用。方法参考有关文献,结合临床用药实际论证给药方案。结果抗生素后效应的存在使药物的有效性得以延长,PAE对确定用药剂量、给药时间和次数具有指导作用。结论结合PAE现象制定的用药方案,既提高了抗菌药物的疗效,又减少了药物费用和毒副作用。 Objective To introduce the guidance of antibacterial PAE on clinical rational drug use and to promote the rational application of antibacterial drugs. Methods Reference to the literature, combined with the actual use of clinical drug administration program. Results The post-antibiotic effect prolonged the effectiveness of the drug, and PAE could guide the determination of dosage, time and number of administration. Conclusions Combined with the PAE phenomenon, the medication regimen not only improves the curative effect of antibacterial drugs, but also reduces the drug cost and side effects.