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目的探讨联合检测催乳激素(PRL)和抗心磷脂抗体(ACA)在子宫内膜异位症(EMS)诊断中的应用价值。方法将90例EMS患者按美国生育学会(AFS)修正的分期法分为轻度组(Ⅰ/Ⅱ期)41例和重度组(Ⅲ/Ⅳ期)49例,以10例正常生育年龄妇女做为对照组。采用时间分辨荧光免疫法检测血清PRL,ELISA法检测血清ACA。结果(1)EMS轻度组和重度组血清PRL水平及ACA阳性率分别为(642.60±419.69)u/ml、(647.97±289.76)u/ml和63.4%、71.4%,差异无统计学意义(P>0.05),但均明显高于健康对照组(P<0.05)。(2)轻度组血清ACA阳性率34.1%,显著高于重度组和对照组(P<0.05)。结论联合检测血清PRL和ACA,有助于EMS的诊断和分期。
Objective To investigate the value of combined detection of prolactin (PRL) and anticardiolipin antibodies (ACA) in the diagnosis of endometriosis (EMS). Methods Forty-nine EMS patients were divided into mild group (stage Ⅰ / Ⅱ), 41 cases and severe group (stage Ⅲ / Ⅳ), 49 cases according to American Society of Fertility (AFS) revision. Ten cases of normal reproductive age women For the control group. Serum PRL was detected by time-resolved fluorescence immunoassay and serum ACA was detected by ELISA. Results (1) Serum PRL levels and ACA positive rates in mild and severe EMS group were (642.60 ± 419.69) u / ml, (647.97 ± 289.76) u / ml and 63.4%, 71.4% respectively, with no significant difference P> 0.05), but both were significantly higher than the healthy control group (P <0.05). (2) The positive rate of ACA in mild group was 34.1%, which was significantly higher than that in severe group and control group (P <0.05). Conclusions Combined detection of serum PRL and ACA is helpful for the diagnosis and staging of EMS.