实体瘤中耐辐射的乏氧细胞的存在,使通常的放射治疗只取得有限的效果,为此采用了新的放射技术,如高压氧,快速中子,π介子束等来提高放疗效果。然而采用药物来增敏乏氧细胞对射线的敏感性也不失为一条合理途径。理想的增敏剂最好是代谢缓慢,并能从毛细血管末端扩散到肿瘤的乏氧细胞中去。已知化合物分子的电子亲合势与放疗增敏能力有关,不少亲电化合物能 The presence of radiation-resistant hypoxic cells in solid tumors has resulted in limited results for usual radiation therapy. New radiological techniques such as hyperbaric oxygen, fast neutrons, and pion beams have been used to improve radiotherapy. However, using drugs to sensitize hypoxic cells to ray sensitivity is also a reasonable approach. Ideal sensitizers are best metabolized slowly and can migrate from the ends of the capillaries to the hypoxic cells of the tumor. The electron affinity of known compounds is related to radiosensitivity, and many electrophilic compounds can