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目的探究阿司匹林对壳聚糖聚集体形成的影响以及阿司匹林/壳聚糖聚集体对阿司匹林的释放性能。方法选用浓度为0.25mol/L和0.3mol/L的柠檬酸溶解壳聚糖并绘制柠檬酸/壳聚糖/温度二元相图。利用阿司匹林与壳聚糖构筑聚集体并进行稳态扫描,测定其流变性质。选用壳聚糖质量分数为2.5%和5.0%的聚集体作为阿司匹林的药物载体进行体外释放,对释放过程进行动力学拟合。结果稳态流变表明阿司匹林/壳聚糖聚集体有较强的假塑性。释放实验中,阿司匹林的释放过程符合一级动力学方程,通过对空白样品对比,4组聚集体对阿司匹林均有缓释效果。结论利用阿司匹林与柠檬酸溶解的壳聚糖构筑的聚集体对药物阿司匹林有着良好的缓释效果。其中柠檬酸浓度为0.3mol/L,壳聚糖质量百分数为5.0%的聚集体包载阿司匹林时,达到最大释放量的时间为10h。
Objective To investigate the effects of aspirin on the formation of chitosan aggregates and the release of aspirin / chitosan aggregates to aspirin. Methods Citric acid was used to dissolve chitosan at a concentration of 0.25 mol / L and 0.3 mol / L and citric acid / chitosan / temperature binary phase diagram was drawn. Aspirin and chitosan were used to construct aggregates and perform steady-state scanning to determine their rheological properties. The aggregates with mass fraction of chitosan of 2.5% and 5.0% were selected as drug carriers of aspirin for in vitro release, and the release kinetics was fitted. Results Steady-state rheology shows that aspirin / chitosan aggregates have strong pseudoplasticity. Release experiment, aspirin release process in line with the first-order kinetic equation, by comparing the blank samples, four groups of aspirin aggregate release effect. Conclusion Aspirin and citric acid dissolved chitosan constructed aggregates of drug aspirin has a good sustained-release effect. The concentration of citric acid 0.3mol / L, the mass percentage of chitosan 5.0% aggregate aspirin, the time to reach the maximum release of 10h.