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目的:综合分析中国妇女子宫内膜癌与Cyclin D1表达的关系,探讨两者的相关性,为子宫内膜癌的临床诊断以及病因研究提供依据。方法:采用Meta分析的方法对所有有关中国人群子宫内膜癌与Cyclin D1表达研究的文献进行汇总、归纳和分析。结果:16篇入选同类文献联合分析发现,子宫内膜癌组织及非典型性增生内膜组织中Cyclin D1的表达率显著高于正常组织,差异有统计学意义(P<0.01);非典型性增生内膜组织中Cyclin D1的表达率与子宫内膜癌组织比较,差异有统计学意义(P<0.05)。结论:Cyclin D1的高表达可能与中国妇女子宫内膜癌的发生具有密切关系。
OBJECTIVE: To analyze the relationship between the expression of Cyclin D1 and the expression of endometrial carcinoma in Chinese women, and to explore the correlation between the expression of Cyclin D1 and endometrial cancer in Chinese women. METHODS: Meta-analysis was used to summarize, summarize and analyze all the literature about the expression of Cyclin D1 and endometrial cancer in Chinese population. Results: The combined analysis of 16 selected literatures showed that the expression of Cyclin D1 in endometrial carcinoma and atypical hyperplasia was significantly higher than that in normal tissues (P <0.01). The atypical The expression of Cyclin D1 in endometrial hyperplasia tissue was significantly higher than that in endometrial carcinoma (P <0.05). Conclusion: The high expression of Cyclin D1 may be closely related to the occurrence of endometrial cancer in Chinese women.