论文部分内容阅读
目的通过观察、评价中药痰热清注射液在老年肺癌(非小细胞肺癌)介入化疗辅助治疗中的疗效,尝试从炎症反应角度探讨清热解毒化痰法在该类疾病治疗中的价值、特点及可能的作用机制。方法将60例老年肺癌患者随机分为对照组、治疗组各30例,分别采用常规介入化疗、常规介入化疗加痰热清注射液治疗,并应用免疫比浊法检测患者治疗前和治疗后(第1、3、7天)超敏C反应蛋白(hs-CRP)水平,并同步进行中医症状、体征评分。结果治疗组与对照组hs-CRP水平及中医症状、体征评分在用药前无显著差异(P>0.05),治疗后均升高(P<0.05);两组治疗7d后hs-CRP水平及中医症状、体征评分比较,差异有统计学意义(P<0.05)。结论痰热清注射液可加快介入化疗后hs-CRP水平的下降,且可有效改善患者肺癌相关的临床症状,提示运用清热解毒化痰法改善肺癌患者炎症反应可能是晚期老年肺癌介入化疗有效的辅助治疗手段之一。
Objective To observe and evaluate the curative effect of traditional Chinese medicine Tanreqing Injection in the adjuvant chemotherapy of elderly patients with lung cancer (non-small cell lung cancer) by interventional chemotherapy, and to explore the value, characteristics and the characteristics of Qingrejiedu Huatan method in the treatment of such diseases from the perspective of inflammatory reaction Possible mechanism of action. Methods Sixty elderly patients with lung cancer were randomly divided into control group and treatment group with 30 cases each. The patients were treated with conventional interventional chemotherapy and Tanreqing injection respectively. Immunoturbidimetry was used to detect the serum levels of 1, 3, 7 days) hs-CRP levels, and simultaneously Chinese medicine symptoms and signs score. Results The levels of hs-CRP, symptoms and signs of TCM in treatment group and control group were not significantly different before treatment (P> 0.05), but were significantly higher after treatment (P <0.05) Symptoms, signs score comparison, the difference was statistically significant (P <0.05). Conclusion Tanreqing injection can speed up the decline of hs-CRP after interventional chemotherapy, and can effectively improve the clinical symptoms of patients with lung cancer, suggesting that the use of detoxification and phlegm method to improve the inflammatory response in patients with lung cancer may be effective in elderly patients with advanced lung cancer interventional chemotherapy One of adjuvant therapy.