应用高脂高糖饮食以及腹腔注射小剂量链脲佐菌素的方法建立2型糖尿病大鼠模型,采用吡格列酮进行干预4周。结果:糖尿病组大鼠血糖、血胰岛素、血脂、MDA、TNF-α水平均明显增高,血管平滑肌细胞增殖程度也增高(P<0.01)。干预后均明显降低。结论:吡格列酮可能成为治疗2型糖尿病大血管并发症的新途径。 The model of type 2 diabetes mellitus was established by using high-fat, high-sugar diet and intraperitoneal injection of low-dose streptozotocin. The rats were treated with pioglitazone for 4 weeks. Results: The levels of blood glucose, blood insulin, blood lipids, MDA and TNF-α were significantly increased and the proliferation of vascular smooth muscle cells was also increased in diabetic rats (P <0.01). After intervention were significantly reduced. Conclusion: Pioglitazone may be a new way to treat macrovascular complications of type 2 diabetes mellitus.