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自噬是指隔离膜包裹细胞质和(或)细胞器形成自噬体,然后与溶酶体融合成自噬溶酶体并在其中降解的过程。自噬性细胞死亡的特征为细胞质中出现大量的自噬体和自噬溶酶体。Beclinl、PIEN可能是自噬相关基因,自噬、自噬性细胞死亡在肿瘤发生、发展中可能发挥重要的作用。
Autophagy is the process by which the isolation membrane encapsulates the cytoplasm and / or organelles to form autophagosomes, which then fuse with and lysate into the autolysosome and degrade in it. Autophagic cell death is characterized by the appearance of large numbers of autophagosomes and autophagy lysosomes in the cytoplasm. Beclinl, PIEN may be autophagy-related genes, autophagy, autophagic cell death may play an important role in tumorigenesis and development.