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１９８６～１９９５年在广东省鼻咽癌高发区对近１０万人，以鼻咽部间接鼻咽镜检查、ＥＢ病毒多种抗体检测、鼻咽光导纤维镜检查、活检组织病理检查及ＥＢ病毒ＤＮＡ、ＥＢＥＲｓ检测等手段进行前瞻性研究。具有下列条件之一者为处于癌前状态：①ＥＢ病毒ＶＣＡ／ＩｇＡ≥１∶８０；②ＥＢ病毒ＥＤＡｂ≥６０％；③ＥＢ病毒ＶＣＡ／ＩｇＡ（≥１∶５）、ＥＡ／ＩｇＡ（≥１∶５）、ＥＤＡｂ（≥３０％）三项中任何双项或三项阳性；④ＥＢ病毒ＶＣＡ／ＩｇＡ、ＥＡ／ＩｇＡ、ＥＤＡｂ三项中任何单项持续高滴度或滴度持续升高。经病理检查：鼻咽粘膜呈中、重度异型增生／化生者应被视为处于癌前病变。凡处于癌前状态或癌前病变者，应被视为鼻咽癌高危人群。为在高发区人群筛查的实施，鼻咽癌Ⅱ级预防确立科学依据。
From 1986 to 1995, there were nearly 100,000 people in the high incidence area of nasopharyngeal carcinoma in Guangdong Province. Indirect nasopharyngeal examination of nasopharynx and nasopharynx, detection of multiple antibodies of Epstein-Barr virus, nasopharyngeal fiberoptic ductoscopy, biopsy and EBV DNA , EBERs test and other means for prospective study. One of the following conditions is in precancerous state: ①EB virus VCA / IgA≥1: 80; ②EB virus EDAb≥60%; ③EB virus VCA / IgA (≥1: 5), EA / IgA , EDAb (≥30%) three any two or three positive; ④EB virus VCA / IgA, EA / IgA, EDAb any one of the three sustained high titer or titer continued to rise. The pathological examination: nasopharyngeal mucosa were moderate and severe dysplasia / metaplasia should be considered in precancerous lesions. Where in pre-cancerous or precancerous lesions, should be considered as high-risk population of nasopharyngeal carcinoma. For the implementation of population screening in high incidence areas, prevention of nasopharyngeal carcinoma Ⅱ establish scientific basis.