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阈下微脉冲激光是近年来应用于眼科的一种以长间歇为特征的激光模式，可以在达到有效治疗效应的同时将其对组织的损伤降到最小，目前已应用于糖尿病黄斑水肿（DME）的治疗。早期研究认为，阈下微脉冲激光选择性地作用于视网膜色素上皮细胞，通过调节炎性生物标志物、生长因子、热休克蛋白等物质的表达达到减轻黄斑水肿的目的。近年来随着研究进展，越来越强调视网膜胶质细胞在DME中的作用，Müller细胞也被认为可能是微脉冲激光作用的靶细胞之一，但目前尚没有微脉冲激光直接或间接作用于Müller细胞的证据。期待不远的将来发现更多阈下微脉冲激光的靶细胞，并通过Müller细胞或Müller细胞与视网膜色素上皮细胞共培养进行体外实验以进一步证实，从而更为详细地探讨阈下微脉冲激光在DME中的作用机制。“,”In recent years, the subthreshold micropulse laser is a kind of laser mode which is characterized by long intermittence. It achieves effective therapeutic effect while minimizes the damage to tissues. At present, it has been used to treat diabetic macular edema. Early studies suggested that the laser selectively acts on retinal pigment epithelial cells to reduce macular edema by regulating the expression of inflammatory biomarkers, growth factors, heat shock proteins and other substances. In recent years, with the development of research, more and more emphasis has been placed on the role of retinal glial cells. Müller cells are also considered as one of the target cells affected by micropulse laser, but there is no evidence of direct or indirect effects of micropulse laser on Müller cells. In the near future, it is expected that we will have more clinical evidence to confirm the target cells of the micropulse laser, which may be further confirmed by in vitro experiments through Müller cells or Müller cells co-cultured with retina pigment epithelium cells, so as to make a more detailed statement on the mechanism of it.