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为了解流脑流行特征及流脑免疫菌株变迁情况,健康人群流脑免疫水平状况及免疫疫苗特点,为制定流脑防控策略提供依据。通过查阅流脑防控相关文献,结合常山县流脑监测资料,研究发现C群流脑菌株已成为中国主要的致病菌群之一,C群流脑在中国已经逐渐成为流行优势菌群;我国健康人群A群、C群流脑抗体均处于较低水平,且从我国目前流脑免疫程序来看,存在<2岁儿童C群流脑并未得到免疫的缺陷,菌群变迁极有可能引起流脑的暴发与流行。建议我国在抓好现有流脑免疫程序落实的同时,宜开展15岁以下儿童A+C双价疫苗的查漏补种工作。针对<2岁儿童存在C群流脑并未得到免疫的缺陷,应积极推广(A+C)群脑膜炎球菌结合菌苗(MCV)接种工作。
In order to understand the epidemiological characteristics of meningitis and the changes of immunocompetent strains of meningococcal meningitis, the status of immunocompromised meningitis in immunocompetent people and the characteristics of immune vaccines, this study may provide evidence for the prevention and control of meningitis. By referring to the literature about prevention and control of meningitis and combining with the monitoring data of meningitis in Changshan County, it has been found that the meningococcal group C has become one of the major pathogenic bacteria in China. The meningitis group C has become a predominant flora in China. Mycobacterium group A and group C meningococcal antibodies are all at a low level in our country, and from the current immunization schedule of meningococcal meningitis in our country, there is a defect that group C meningitis in children <2 years old has not been immunized, Cause meningococcal outbreak and epidemic. Suggest that our country do a good job in the existing program of immunization of meningitis at the same time, should be carried out under the age of 15 A + C bivalent vaccine leak detection and replant work. For children <2 years old, there is no immunodeficiency in group C meningitis, and group A + C meningococcal vaccine (MCV) vaccination should be actively promoted.