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[背景]血压升高与颗粒物(PM)空气污染相关,但是与PM化学成分的关联尚不明确。[目的]通过对一组39名大学生进行460次反复访查,探讨血压与不同化学成分的细颗粒物(PM2.5)之间的关联。[方法]采用标准化方法,测量中国北京的大学生在校园搬迁前后的静息血压,这些学生的校园从郊区搬迁到市区,两个地区的空气污染程度不同。空气污染数据来自于靠近学生宿舍的中央监视器。使用混合效应模型来估计不同的PM2.5成分与收缩压(SBP)、舒张压(DBP)和脉压的相关性。[结果]PM2.5中四分位数间距增加51.2μg/m3与次日SBP升高1.08mmHg(95%CI:0.17~1.99)以及DBP升高0.96mmHg(95%CI:0.31~1.61)相关。PM2.5成分的一个亚组,包括含碳成分(有机碳和元素碳)、离子(氯化物和氟化物)和金属/金属元素(镍、锌、镁、铅和砷),与不同的血压变化有很强的正相关关系,锰、铬和钼与SBP或DBP有很强的负相关关系。[结论]研究结果支持特定的PM2.5成分与BP之间存在关联。这些发现对最大限度地保护公共健康利益的污染治理发展战略具有潜在的影响。
[Background] Elevated blood pressure correlates with particulate matter (PM) air pollution, but the association with PM chemistry is unclear. [Objective] To investigate the relationship between blood pressure and PM2.5 in different chemical composition through 460 repeated visits to a group of 39 college students. [Method] The standardized method was used to measure the resting blood pressure before and after the relocation of college students in Beijing, China. The students’ campuses were moved from the suburbs to the urban areas, and the air pollution levels in the two areas were different. Air pollution data come from a central monitor near the student residence. A mixed effect model was used to estimate the association of different PM2.5 components with systolic (SBP), diastolic (DBP) and pulse pressure. [Results] The interquartile range of PM2.5 increased 51.2μg / m3 with the next day’s SBP increased 1.08mmHg (95% CI: 0.17-1.99) and increased DBP 0.96mmHg (95% CI: 0.31-1.61) . A subset of the PM2.5 components include carbonaceous components (organic carbon and elemental carbon), ions (chloride and fluoride) and metal / metal elements (nickel, zinc, magnesium, lead and arsenic), with different blood pressure There is a strong positive correlation between manganese, chromium and molybdenum and SBP or DBP has a strong negative correlation. [Conclusions] The findings support the association of a specific PM2.5 component with BP. These findings have the potential to impact on pollution-control development strategies that maximize public health benefits.