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目的:了解载脂蛋白E(ApoE)基因多态性与脑梗塞之间的关联。方法:应用聚合酶链反应-限制性片段长度多态性分析,对120例脑梗塞及120例正常对照的ApoE基因多态性进行分析。结果:脑梗塞组与对照组相比,ε3/3基因型频率(0·6917vs0·8333,P=0·015)及ε3等位基因频率显著降低(0·7708vs0·8958,P=0·000);ε4等位基因频率显著增高(0·1500vs0·0667,P=0·005)。结论:ApoEε3/3基因型及ε3等位基因可能是脑梗塞的保护因素,ε4等位基因可能是脑梗塞的危险因素。
Objective: To understand the association between apolipoprotein E (ApoE) gene polymorphism and cerebral infarction. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the polymorphism of ApoE gene in 120 cases of cerebral infarction and 120 cases of normal controls. Results: Compared with the control group, the frequency of ε3 / 3 genotype (0.6917 vs 0.0333, P = 0.015) and ε3 allele in cerebral infarction group were significantly lower than those in control group (0.7708 vs 0.08995, P = 0.000 ); ε4 allele frequency was significantly higher (0 · 1500vs0 · 0667, P = 0.005). Conclusion: The ApoEε3 / 3 genotype and ε3 allele may be the protective factors of cerebral infarction. The ε4 allele may be the risk factor of cerebral infarction.