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目的 了解可溶性肿瘤坏死因子受体 -Ⅰ (sTNFR -Ⅰ )在消化道恶性肿瘤患者中的临床意义。方法 应用双抗体夹心ELISA法 ,对 37例食管癌、41例胃癌、30例大肠癌患者血清sTNFR -Ⅰ水平进行了检测。结果 三组肿瘤患者血清sTNFR -Ⅰ水平显著高于对照组 ,且随肿瘤临床病理分期增加而增高 ,有转移者显著高于无转移者。手术切除肿瘤后sTNFR -Ⅰ水平下降 ,肿瘤复发时sTNFR -Ⅰ水平上升。结论 检测血清sTNFR -Ⅰ水平有助于消化道恶性肿瘤患者的诊断及预后判断
Objective To understand the clinical significance of soluble tumor necrosis factor receptor-Ⅰ (sTNFR-Ⅰ) in patients with gastrointestinal cancer. Methods Serum sTNFR-Ⅰ levels in 37 cases of esophageal cancer, 41 cases of gastric cancer and 30 cases of colorectal cancer were detected by double antibody sandwich ELISA. Results The serum levels of sTNFR-Ⅰ in the three groups of patients were significantly higher than those in the control group. The levels of sTNFR-Ⅰ in the three groups were significantly higher than those in the control group, and were significantly higher than those without metastasis. The level of sTNFR-I decreased after surgical resection and the level of sTNFR-I increased during tumor recurrence. Conclusion The detection of serum sTNFR-Ⅰ level is helpful to the diagnosis and prognosis of patients with gastrointestinal cancer