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目的探讨解脲脲原体、沙眼衣原体和男性不育之间的关系。方法运用计算机检索和手工检索相结合的方法,系统检索1994年1月至2014年5月关于男性不育的文献。数据库包括中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方(Wanfang)以及维普(VIP);Pubmed、Cochrane library、Highwire以及Google scholar。按照纳入及排除标准筛选文献后运用Stata12.0软件对提取数据进行Meta分析。结果最终纳入文献42篇,其中仅含有UU的26篇,仅含有CT的7篇,两者都有的9篇。UU感染对男性不育的汇总效应OR=5.03,95%CI=4.45~5.69(P<0.001),而CT感染得到的汇总效应OR=4.34,95%CI=3.03~6.23(P<0.001),两个因素对男性不育的影响均有统计学意义。结论 UU感染和CT感染均为男性不育的危险因素,感染者不育风险分别增加5.03倍和4.34倍。
Objective To explore the relationship between Ureaplasma urealyticum, Chlamydia trachomatis and male infertility. Methods The methods of computer and manual retrieval were used to systematically search the literature about male infertility from January 1994 to May 2014. The database includes CBM, CNKI, Wanfang and VIP; Pubmed, Cochrane library, Highwire and Google Scholar. According to inclusion and exclusion criteria after screening the literature using Stata12.0 software to extract data for Meta analysis. The results were included in the final 42 articles, which contains only 26 UU, containing only 7 CT, 9 of both. The overall effect of UU infection on male infertility was 5.03, 95% CI = 4.45-5.69 (P <0.001), while the cumulative effect of CT infection was OR = 4.34,95% CI 3.03-6.23 (P <0.001) The two factors have a significant effect on male infertility. Conclusions Both UU and CT infection are risk factors for infertility in men, and the risk of infertility is 5.03 times and 4.34 times higher respectively.