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目的探讨α-干扰素、不同剂量静脉用丙种球蛋白(IVIG)治疗儿童特发性血小板减少性紫癜(ITP)的疗效。方法将102例ITP患儿随机分为3组(每组各34例):A组为常规剂量IVIG治疗、B组干扰素治疗、C组干扰素联合小剂量IVIG治疗;3组均常规应用肾上腺皮质激素、Vit-C等药物。随访6个月,评价疗效。结果 C组在血小板开始上升时间、血小板升至正常时间、平均住院天数、激素使用时间等方面优于A、B2组(P<0.01或P<0.05);在复发率方面优于A组(P<0.05),与B组相比,差异无统计学意义(P>0.05);而在住院费用方面A组高于B、C2组(P均<0.01),B组低于C组(P<0.05)。各组患儿在治疗过程中均未见不良反应发生。结论干扰素联合小剂量IVIG在ITP的治疗中为最优方案。
Objective To investigate the curative effect of α-interferon and intravenous gamma globulin (IVIG) on children with idiopathic thrombocytopenic purpura (ITP). Methods A total of 102 children with ITP were randomly divided into 3 groups (34 in each group): group A received conventional IVIG treatment, group B received interferon treatment and group C received interferon plus low-dose IVIG. All three groups were given adrenal Corticosteroids, Vit-C and other drugs. Follow-up 6 months, evaluate the efficacy. Results Group C was superior to group A and B2 (P <0.01 or P <0.05) in terms of platelet rise time, platelet up to normal time, average length of hospital stay, hormone usage time, etc. (P <0.05). There was no significant difference between group A and B (P> 0.05), while group A was higher than group B and C2 (P <0.01), while group B was lower than group C (P < 0.05). Each group of children in the course of treatment were no adverse reactions occurred. Conclusion Interferon combined with low-dose IVIG is the optimal treatment for ITP.