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目的探讨环境双酚A(BPA)暴露与人群糖尿病的关系。方法以计算机检索中外期刊数据库[包括中国学术期刊全文数据库(CNKI)、万方数据知识服务平台全文数据库、维普中文科技期刊全文数据库(VIP)、Pub Med、EBSCO、Elsevier Science direct、Medical Evidence Matters Archive],收集各数据库从建库至2016年4月有关BPA暴露对糖尿病患病影响公开发表的文献。按照文献纳入排除标准筛选文献后进行meta分析。结果最终纳入9篇文献共10个研究。meta分析结果显示整体合并效应值OR为1.32(95%CI:1.15~1.52,P<0.01);2型糖尿病、妊娠期糖尿病以及不区分糖尿病类型三组研究进行亚组分析,各自合并OR值分别为1.19(95%CI:0.99~1.42)、0.70(95%CI:0.27~1.79)以及1.80(95%CI:1.39~2.34),结合漏斗图和Egger回归分析(P=0.691)发现纳入文献不存在发表偏倚。结论较高BPA暴露可增加整体糖尿病的患病风险,但对不同类型糖尿病作用可能存在差异。
Objective To investigate the relationship between environmental bisphenol A (BPA) exposure and population diabetes mellitus. Methods The databases of Chinese and foreign periodicals were searched by computer (including CNKI, Wanfang Data Knowledge Service Platform, VIP, Pub Med, EBSCO, Elsevier Science direct, Medical Evidence Matters Archive ] To collect the published data on the impact of BPA exposure on the prevalence of diabetes from the database to April 2016. According to the literature included in the exclusion criteria screening after meta-analysis. The results of the final inclusion of 9 articles a total of 10 studies. The meta-analysis showed that the OR of the overall combined effect was 1.32 (95% CI: 1.15-1.52, P <0.01). Subgroup analyzes were conducted in the three groups of type 2 diabetes mellitus, gestational diabetes mellitus and undifferentiated diabetes mellitus type. Were found to be 1.19 (95% CI: 0.99 to 1.42), 0.70 (95% CI: 0.27 to 1.79), and 1.80 (95% CI: 1.39 to 2.34) in combination with funnel plot and Egger regression analysis (P = 0.691) There is publication bias. Conclusion Higher BPA exposure may increase the overall risk of diabetes, but may have different effects on different types of diabetes.