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目的:评价银杏叶制剂对比其他制剂治疗不稳定型心绞痛的疗效及应用安全性。方法:采用系统评价的方法,采用计算机检索搜集银杏叶制剂治疗不稳定型心绞痛的随机对照试验(RCT),并进行分析。结果:共纳入23个RCT,2494例患者。行Meta分析显示银杏叶制剂组临床症状有效率优于对照组,差异有统计学意义;因多数研究仅报道了“未见不良反应”字样,故未作Meta分析以了解组间事件发生率及不良反应情况。结论:现有证据支持银杏叶制剂治疗不稳定型心绞痛具有较好疗效,但尚需进行设计合理、执行严格、多中心大样本且随访时间足够的随机对照试验进一步证实结论。
Objective: To evaluate the efficacy and safety of Ginkgo biloba preparation compared with other preparations in the treatment of unstable angina pectoris. Methods: A systematic review was conducted to evaluate the RCT of Ginkgo biloba extract in patients with unstable angina pectoris by computerized searching. Results: A total of 23 RCTs and 2494 patients were enrolled. Meta-analysis showed that the clinical symptoms of Ginkgo biloba preparation group was better than that of the control group, and the difference was statistically significant. Meta analysis was not conducted to understand the incidence of inter-group events because most studies only reported the words “no adverse reactions” Rate and adverse reactions. CONCLUSION: The available evidence supports the efficacy of Ginkgo biloba extract in the treatment of unstable angina pectoris. However, it still needs to be confirmed by randomized controlled trials with well-designed, well-executed, multi-center large sample and sufficient follow-up time.