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利用ribozyme专一水解RNA的特性,设计ribozyme定点切割基因表达的中间物mRNA以及病毒RNA,可以阻断基因表达和抑制病毒复制,从而达到治病和防病的目的。自1990年以来,利用ribozyme技术,已经对爱滋病、肿瘤等疾病进行了大量的研究。本文着重介绍ribozyme体内阻断基因表达的应用和一些规律性问题。
The use of ribozyme specific hydrolysis of RNA properties, design ribozyme site-directed cutting gene expression mRNA and viral RNA, can block gene expression and inhibit viral replication, so as to achieve the purpose of treatment and prevention. Since 1990, a great deal of research has been conducted on diseases such as AIDS and cancer using ribozyme technology. This article highlights the use of ribozyme in vivo to block gene expression and some of the regulatory issues.