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目的:探讨肝癌患者行肝癌切除术后细胞免疫的变化及其意义。方法:选择90例肝癌患者作为病例组,选择同期健康体检者90例作为对照组,检测病例组患者术前、术后7,14 d以及对照组T淋巴细胞亚群,包括CD3+,CD4+,CD8+,CD4+/CD8+。结果:病例组CD3+,CD4+,CD4+/CD8+均低于对照组,CD8+高于对照组,且差异均有统计学意义(P<0.05);病例组术后7 d CD3+,CD4+,CD4+/CD8+均低于术前,CD8+高于术前,且差异均有统计学意义(P<0.05);术后14 d CD3+,CD4+,CD8+,CD4+/CD8+与术前比较,差异无统计学意义(P>0.05);T1,T2期CD3+,CD4+,CD4+/CD8+均明显高于T3,T4期,而CD8+明显低于T1,T2期。结论:肝癌患者细胞免疫处于抑制状态,并与肝癌分期有关,手术后7 d内左右细胞免疫抑制情况会更加严重,之后免疫功能逐渐恢复,肝癌手术患者应该及时进行免疫干预,提高免疫功能,改善治疗效果。
Objective: To investigate the changes and significance of cellular immunity after liver cancer resection in patients with liver cancer. Methods Ninety patients with hepatocellular carcinoma (HCC) were enrolled in this study. Totally 90 healthy subjects were selected as the control group. The T lymphocyte subsets including CD3 +, CD4 +, CD8 + , CD4 + / CD8 +. Results: The levels of CD3 +, CD4 +, CD4 + / CD8 + were significantly lower in case group than in control group and CD8 + was higher than that in control group (P <0.05) (P <0.05). There was no significant difference in CD3 +, CD4 +, CD8 +, CD4 + / CD8 + levels between preoperative and postoperative levels of CD8 + 0.05). CD3 +, CD4 +, CD4 + / CD8 + of T1 and T2 were significantly higher than those of T3 and T4, while CD8 + was lower than T1 and T2. CONCLUSIONS: The cellular immunity of HCC patients is in an inhibitory state and is related to the staging of HCC. The immunosuppression will be more serious around 7 days after operation, and the immune function gradually recovers. The patients with HCC should be immunized in time to improve the immune function and improve the immune function treatment effect.