乙酰肝素酶是一种内源葡萄糖醛酸酶 ,与肿瘤转移密切相关 ,最近 3家实验室独立地克隆出其基因 ,为研究肿瘤转移开辟了一个很有潜力的领域。随着有关乙酰肝素酶分子生物学特性、调节因素、抑制剂等方面研究的不断深入 ,乙酰肝素酶很可能成为抗癌药物的靶子。 Heparanase is an endogenous glucuronidase and is closely related to tumor metastasis. Recently, three laboratories independently cloned their genes, opening up a promising field for the study of tumor metastasis. With the deepening of research on molecular biology characteristics, regulatory factors, and inhibitors of heparanase, heparanase is likely to become the target of anti-cancer drugs.