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研究小量α-HANP对6例充血性心衰患者的血液动力学及肾脏效应。给药后,患者心排血量及排血指数明显上升;心腔压力、体及肺循环阻力大多下降;血压、心率及呼吸轻微下降;尿量及尿钠排出增加;心衰情况明显改善;室性早搏显著减少。未见明显副作用。着重指出与动物及正常人中应用α-HANP后的结果有所不同。
To investigate the hemodynamic and renal effects of a small dose of α-HANP in 6 patients with congestive heart failure. After administration, the patient’s cardiac output and discharge index increased significantly; heart pressure, body and pulmonary resistance mostly decreased; blood pressure, heart rate and respiratory depression decreased slightly; urine output and urinary sodium excretion increased significantly; heart failure was significantly improved; Premature contractions significantly reduced. No obvious side effects. Highlighting the difference between the results of using α-HANP in animals and normal subjects.