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目的：探讨Binswanger病患者核心家庭成员的载脂蛋白（a）［apo（a）］和载脂蛋白E（apoE）多态性分布和等位基因频率。方法：疾病组患者35例，配偶组33例，子女组31例，对照组63例。采用免疫印迹技术检测刎apo（a）和apoE多态性分布，并推算等位基因频率。结果：疾病组与对照组间载脂蛋白表型分有存在明显差异，配偶组与对照组间无明显差异，患者与子女间相似。各组S4、E3等位基因频率最高。与对照组Binswanger病患者S2、E4等位基因频率高于正常人群，这种改变可能与患者发病有关。
Aims: To investigate apolipoprotein (a) [apo (a)] and apolipoprotein E (apoE) polymorphism distribution and allele frequencies among core family members of patients with Binswanger’s disease. Methods: 35 patients in the disease group, 33 spouses, 31 children and 63 control subjects. Western blotting was used to detect the distribution of 刎 apo (a) and apoE polymorphisms and to estimate the allele frequency. Results: There was a significant difference in the apolipoprotein phenotypes between the disease group and the control group. There was no significant difference between the spouses group and the control group. The patients and their children were similar. Each group S4, E3 allele frequency highest. Compared with control group, the frequency of S2 and E4 alleles in Binswanger’s disease patients was higher than that in normal people, which may be related to the onset of the disease.