Simoni 等于1983年介绍了用 CVS(Chorionic villus samples)的直接染色体分析作胎儿细胞遗传学诊断比妊娠中期的羊水细胞染色体分析有了明显的优点。在最适宜的条件下,将 CVS 到作出细胞遗传学诊断的时间缩短在几小时内,如需要治疗性流产则可在几天内进行,如此会减轻用孕中期产前诊断病人所受到的精神压力。尽管有这些 Simoni et al., 1983 introduced the direct chromosomal analysis of CVS (Chorionic villus samples) for fetal cytogenetic diagnosis of meconium than mid-pregnancy amniotic fluid chromosome analysis has obvious advantages. Under the most appropriate conditions, reducing the time it takes CVS to make cytogenetic diagnoses within a matter of hours, or treating abortion if required, can be done in a matter of days, thus alleviating the mental retardation of prenatal diagnosis in the second trimester pressure. Despite these