中枢多巴胺受体包括D1R和D2 R两大类 ,又各有不同的亚型 ,在机体的体温调节中发挥重要作用 ,但多巴胺受体不是参与体温调节的惟一因素。本文对多巴胺受体激动剂和拮抗剂的作用特异性进行了重新评价 ,并总结讨论了两大类多巴胺受体在体温调节中的作用。D1R的活化能够介导体温的下降 ,而D2 R是介导静息体温和稳定体温的主要因素。多巴胺受体之间以及与其他神经递质系统之间存在相互调节和协同作用 ,共同维持体温平衡 Central dopamine receptors, including D1R and D2R two categories, each with different subtypes, plays an important role in the body’s thermoregulation, but dopamine receptors are not the only factors involved in the regulation of body temperature. In this article, the functional specificity of dopamine receptor agonists and antagonists has been reassessed and the role of the two major classes of dopamine receptors in the regulation of body temperature has been summarized. D1R activation can mediate the decline of body temperature, and D2R is the main factor mediating resting body temperature and stable body temperature. Dopamine receptors, as well as with other neurotransmitter systems exist between the mutual regulation and synergy to maintain body temperature balance