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通过一种具有纳米级分辨率的磁钳技术(magnetic tweezer)和酵母菌,研究人员揭示了喜树碱制剂托泊替康的作用机制。细胞在复制过程中,DNA需要解开其双螺
Using a magnetic tweezer and yeast with nano-scale resolution, researchers revealed the mechanism of action of topotecan, a topical camptothecin. The DNA needs to unwind its double helix in the process of replication