1959年 Prinzmetal 报道了变异型心绞痛,并确定这种心绞痛系冠状动脉痉挛所致。近年来,临床和实验研究中所获得的许多新资料,特别是冠状动脉造影的发展、完善和广泛应用提供了诊断冠状动脉痉挛的重要依据,而且表明冠状动脉痉挛可能在缺血性心脏病发病机理上有重要作用。文献曾报告冠状动脉痉挛在选择性冠状动脉造影时发生率为 Prinzmetal reported variant angina in 1959 and determined that the angina is caused by coronary spasm. In recent years, many new data obtained in clinical and experimental studies, especially the development, improvement and extensive application of coronary angiography provide an important basis for the diagnosis of coronary artery spasm, and show that coronary artery spasm may be involved in the pathogenesis of ischemic heart disease Mechanism has an important role. Literature has reported coronary artery spasm in the incidence of selective coronary angiography