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目的:探讨中国北方平原地区汉族男子脑型肌酸激酶(CKB)基因多态性与耐力训练效果的关联性。方法:102名无训练史的健康男子进行18周有氧耐力训练,测试训练前后的最大摄氧量、跑节省化(RE)各指标。用PCR-RFLP法分析CKB基因启动子上rs3759582和rs3759584两位点的单核苷酸多态性。结果:二个多态位点均符合H-W平衡,不存在强的连锁关系;训练后rs3759582位点AA基因型最大摄氧量变化率、跑节省化变化率与AC基因型组间均无显著性差异(P>0.05);训练后rs3759584位点TT基因型△RE/VO2、△RE/rVO2、△RE/HR和△RE/VE显著低于CT和CC基因型(P<0.05),但是CC基因型频率仅为3%。结论:CKB基因的rs3759582多态性不是预测个体耐力训练敏感性的基因标记;rs3759584与个体的耐力训练敏感性相关,但需加大样本进一步确认。
Objective: To investigate the association of brain-type creatine kinase (CKB) gene polymorphism with endurance training in Han Chinese men in the northern part of China. Methods: A total of 102 healthy men without training history were trained in aerobic endurance training for 18 weeks. The maximal oxygen uptake before and after training and the indexes of saving and running (RE) were tested. The single nucleotide polymorphisms of rs3759582 and rs3759584 at CKB gene promoter were analyzed by PCR-RFLP. Results: The two polymorphic loci were in accordance with the HW balance, there is no strong linkage relationship; AA genotype rs3759582 locus after training the maximum rate of change of oxygen uptake, run saving rate of change and AC genotype were no significant (P> 0.05). The TT genotype △ RE / VO2, △ RE / rVO2, △ RE / HR and △ RE / VE of rs3759584 were significantly lower than those of CT and CC genotypes The genotype frequency is only 3%. Conclusion: The rs3759582 polymorphism of CKB gene is not a genetic marker to predict the sensitivity of endurance training. Rs3759584 is related to the sensitivity of endurance training of individual, but the sample needs further investigation.