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[目的 ]比较氯喹在正常小鼠、感染伯氏疟原虫药物敏感 (N)株和氯喹抗药性 (RC)株小鼠体内的药物动力学差异。 [方法 ]应用反相高效液相色谱法分别测定正常小鼠、感染伯氏疟原虫N株和RC株小鼠血浆中的氯喹浓度 ,采用 3P87药物动力学分析软件对数据进行分析 ,从而获得有关药物动力学参数。 [结果 ]感染RC鼠的t1/2 β与其他两组间有显著的统计学差异 (P <0 .0 5 ) ,而感染N株鼠与正常鼠间无显著差异。 [结论 ]氯喹在感染了伯氏疟原虫RC株鼠体内的消除速度显著快于正常鼠及感染N株鼠。
[Objective] To compare the pharmacokinetics of chloroquine in normal mice, Plasmodium berghei-infected (N) and chloroquine resistant (RC) strains. [Methods] The concentrations of chloroquine in plasma of normal mice, Plasmodium berghei N strain and RC strain mice were determined by RP-HPLC. The data of 3P87 pharmacokinetic analysis software were used to get the correlation Pharmacokinetic parameters. [Results] There was a significant difference (P <0.05) between t1 / 2 β and other two groups in infected RC rats, but there was no significant difference between infected and normal mice. [Conclusion] The elimination rate of chloroquine in RC strain infected with P. berghei was significantly faster than that in normal mice and N infected mice.