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充血性心力衰竭(CHF)时,交感神经系统和肾素-血管紧张素系统激活,以致血浆去甲肾上腺素水平和肾素活性增加。血管紧张素转换酶(ACE)抑制剂虽然有效,但长程治疗中血浆去甲肾上腺素水平仍可继续升高,这说明 ACF抑制剂并不能长期抑制反射性交感神经系统激活。本文评价β受体阻滞剂布新洛尔(bucindolol)对 CHF 患者血浆肾素活性和去甲肾上腺素水平的影响。
During congestive heart failure (CHF), the sympathetic nervous system and the renin-angiotensin system are activated, resulting in an increase in plasma norepinephrine levels and renin activity. Although ACE inhibitors are effective, plasma norepinephrine levels may continue to increase during long-term treatment, suggesting that ACF inhibitors do not inhibit reflex sympathetic activation over the long term. This article evaluates the effect of the beta-blocker bucindolol on plasma renin activity and norepinephrine levels in CHF patients.