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目的研究F框/WD-40域蛋白7(FBXW7)和类固醇受体辅助活化因子3(SRC-3)在胃癌中的表达及临床意义。方法应用免疫组织化学法检测FBXW7和SRC-3在胃癌及正常黏膜组织中的表达。结果 FBXW7在胃癌和正常黏膜组织中的表达率分别为46.7%和90.0%,二者差异有统计学意义(P<0.01),且与胃癌的分化程度、淋巴结转移及临床分期有关(P<0.05);SRC-3在胃癌和正常黏膜组织中的表达率分别为48.3%和10.0%,二者差异有统计学意义(P<0.01),且与胃癌的浸润深度、淋巴结转移及临床分期有关(P<0.05);FBXW7与SRC-3之间存在着负相关关系(r=-0.370,P=0.004)。结论 FBXW7和SRC-3有可能成为胃癌早期诊断、判断预后的新指标及治疗靶点。
Objective To investigate the expression and clinical significance of F-box / WD-40 domain protein 7 (FBXW7) and steroid receptor-assisted activator 3 (SRC-3) in gastric cancer. Methods The expression of FBXW7 and SRC-3 in gastric cancer and normal mucosa were detected by immunohistochemistry. Results The positive rates of FBXW7 in gastric cancer and normal mucosa tissues were 46.7% and 90.0%, respectively, with statistical significance (P <0.01), and were correlated with the degree of differentiation, lymph node metastasis and clinical stage (P <0.05) ). The expression rates of SRC-3 in gastric cancer and normal mucosa were 48.3% and 10.0%, respectively, which were significantly different between the two groups (P <0.01), and were related to the depth of invasion, lymph node metastasis and clinical stage P <0.05). There was a negative correlation between FBXW7 and SRC-3 (r = -0.370, P = 0.004). Conclusion FBXW7 and SRC-3 may become the new target and target of early diagnosis and prognosis of gastric cancer.