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口腔粘膜粘附给药系统是近年来发展的一种新型生物粘附给药系统 ,是近年来药剂学的研究热点 ,它利用粘附性的聚合物为载体 ,通过载体的生物粘附作用 ,延长制剂在口腔的滞留时间而发挥局部疗效和全身治疗作用 ,可以避免药物在胃肠道降解和肝脏的首过效应 ,提高药物的生物利用度 ,同时具有缓释和定位的优点 ,具有广阔的应用前景。本文根据国内外有关口腔粘膜粘附给药制剂的现状及研究动态 ,对口腔粘附给药系统研究中的药物吸收特点、粘附剂的选择、剂型及发展趋向等进行了综述 ,为开展药物新剂型研究提供参考
Oral mucosal adhesion drug delivery system is a new type of bioadhesive drug delivery system developed in recent years. It is a hot research topic in pharmacy in recent years. It uses adhesive polymer as carrier and bioadhesive effect of carrier, Prolong the residence time in the oral cavity to exert local curative effect and systemic therapeutic effect, which can avoid the first pass effect of the drug in the gastrointestinal tract degradation and the liver, improve the bioavailability of the medicine, has the advantages of slow release and location, has broad Application prospects. In this paper, based on the current status and research trends of oral mucosal adherent preparation both at home and abroad, the characteristics of drug absorption in oral adherent delivery system, the selection of adhesive, formulation and development trend are reviewed. New formulations for reference