论文部分内容阅读
采用丙二酸和N-甲基脲为原料,经环合和卤代两步反应得到3-甲基-6-氯尿嘧啶,总收率为61.5%。该化合物是合成治疗Ⅱ型糖尿病药——阿格列汀的关键中间体。
Using malonic acid and N-methylurea as raw materials, 3-methyl-6-chloro-uracil was obtained by cyclization and halogenation in a total yield of 61.5%. This compound is the key intermediate for the synthesis of alogliptin, a type II diabetes drug.