论文部分内容阅读
目的 比较CHOP PVP与CHOP方案治疗非霍奇金淋巴瘤 (NHL)的疗效。方法 79例NHL患者采用CHOP PVP方案治疗 4 0例 ,采用CHOP方案治疗 39例。采用Kaplan Meier方法分析患者治疗后的生存期 ,采用Cox比例风险模型分析影响预后的因素。结果 CHOP PVP方案组完全缓解率 5 7.5 % (2 3/ 4 0 ) ,总有效率 87.5 % (35 / 4 0 ) ;CHOP方案组完全缓解率 33.3% (13/ 39) ,总有效率 6 9.2 %(2 7/ 39)。两组完全缓解率差异有显著性 (P <0 .0 5 ) ,总有效率差异有显著性 (P <0 .0 5 )。两组患者的主要毒副反应为骨髓抑制。白细胞下降CHOP PVP组为 82 .5 % ,CHOP组为 71.8% (P >0 .0 5 ) ,但均无Ⅳ度下降发生 ,亦无与毒性有关的死亡发生。结论 CHOP PVP方案具有有效率高、副反应无明显加重的优点 ,可替代经典的CHOP方案治疗NHL。
Objective To compare the efficacy of CHOP PVP and CHOP in the treatment of non-Hodgkin’s lymphoma (NHL). Methods 79 patients with NHL were treated with CHOP PVP regimen and 40 patients treated with CHOP regimen. The Kaplan-Meier method was used to analyze the survival of patients after treatment. The Cox proportional hazards model was used to analyze the prognostic factors. Results The CHOP PVP group had a complete response rate of 7.57% (23/40) and a total effective rate of 87.5% (35/40). The CHOP regimen group had a complete response rate of 33.3% (13/39) and a total effective rate of 6 9.2 % (2 7/39). There was significant difference between the two groups in the complete remission rate (P <0.05), the total effective rate was significantly different (P <0.05). The main adverse reaction in both groups was myelosuppression. Leukopenia was 82.5% in the CHOP PVP group and 71.8% in the CHOP group (P> 0.05), but no grade Ⅳ degeneration occurred and no toxicity-related death occurred. Conclusion The CHOP PVP regimen has the advantages of high efficiency and no obvious side effects. It can replace the classical CHOP regimen in the treatment of NHL.