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促甲状腺激素释放激素(TRH)能刺激垂体释放促甲状腺激素(TSH),TRH 试验对甲低和甲亢是最敏感和具有诊断价值的方法。本研究目的是为了确定TRH 经鼻吸入的效力,并与静脉法或口服法比较。受试者为21名(女10,男11,平均年龄24岁)健康人。从病史和体格检查中均未发现他们有甲状腺疾病。所有受试者均接受鼻内吸入和口服 TRH 两种投药法;其中13人还接受了静脉 TRH 投药.鼻内给药法以1%TRH 水溶液雾化送入鼻孔,总量2mg;缓慢静脉给药剂量200μg;口服量40mg。
Thyrotropin releasing hormone (TRH) can stimulate the release of thyroid stimulating hormone (TSH) from the pituitary. The TRH test is the most sensitive and diagnostic method for hypothyroidism and hyperthyroidism. The purpose of this study was to determine the efficacy of nasal inhalation of TRH and to compare it with either intravenous or oral administration. The subjects were 21 healthy women (10 males, 11 men and 24 years old on average). They have not been found to have thyroid disease from their medical history and physical examination. All subjects received both intranasal and oral TRH dosing regimens, 13 of whom also received intravenous TRH, intranasally administered as a 1% TRH aqueous solution into the nostrils for a total of 2 mg, and slow intravenous Drug dose 200μg; oral dose of 40mg.