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用流感病毒鼠肺适应株（ＦＭ１） 感染的小鼠肺炎模型，研究宣肺解毒颗粒剂对病毒性肺炎小鼠血浆中细胞因子水平的影响。结果表明：病毒感染组较正常动物对照组血浆中ＩＬ＿１ 及ＩＦＮ＿γ水平显著降低（ Ｐ＜ ０－０１） ，ＴＮＦ＿α水平明显增高，ＩＬ＿２ 仅有降低趋势（ Ｐ＞０－０５） ，提示病毒感染可使机体免疫状态发生显著变化。用宣肺解毒颗粒剂治疗后，血浆中ＩＬ＿２ 及ＩＦＮ＿γ水平均显著升高（ Ｐ＜ ０－０５ ，０－０１） ；ＴＮＦ＿α则显著降低；ＩＬ＿１ 水平有升高趋势，表明本药能够提高ＩＬ＿２ 及ＩＦＮ＿γ水平而增强机体抗病毒感染的免疫功能，并通过抑制ＴＮＦ＿α的过量产生，减轻免疫病理损害。
The effect of Xuanfei Jiedu Granules on plasma cytokine levels in mice with viral pneumonia was studied using a mouse model of pneumonia in mice infected with influenza virus-adapted strain (FM1). The results showed that plasma levels of IL-1 and IFN-γ in the virus-infected group were significantly lower than those in the normal control group (P<0-01), TNF-α levels were significantly higher, and IL-2 only decreased (P>0-05), suggesting that viral infections could be The immune status of the body changes significantly. After treatment with Xuanfei Jiedu Granules, the levels of plasma IL-2 and IFN-γ increased significantly (P<0-05, 0-01); TNF-α decreased significantly; IL_1 levels increased, indicating that the drug can increase IL_2 and IFN-γ levels enhance the body’s immune function against viral infections and reduce immunopathological damage by inhibiting the overproduction of TNF-α.